Molecular Cell
Volume 37, Issue 6, 26 March 2010, Pages 809-820
ArticleYeast Pre-rRNA Processing and Modification Occur Cotranscriptionally
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open access
Graphical Abstract
Highlights
► Fast labeling was developed to provide kinetic data for modeling of rRNA synthesis ► The model indicated a high degree of cotranscriptional pre-rRNA cleavage ► This suggested that rRNA modification would also occur on nascent transcripts ► Further labeling confirmed substantial methylation of nascent pre-rRNA transcripts
RNA
SYSBIO
DNA
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Present address: Biochemistry Center, University of Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
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