Original ResearchMist1 Expression Is Required for Paneth Cell Maturation
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Graphical abstract
Keywords
MIST1
Paneth Cells
Intermediate Cells
Abbreviations used in this paper
CldU
5-chloro-2′-deoxyuridine
DBZ
dibenzazepine
IdU
5-iodo-2′-deoxyuridine
ISC
intestinal stem cell
PBS
phosphate-buffered saline
PTAB
phloxine/tartrizine-alcian blue
RER
rough endoplasmic reticulum
RT
room temperature
TEM
transmission electron microscopy
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Author contributions CMD: study concept and design, acquisition of data, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript for important intellectual content, statistical analysis, obtained funding; SK: acquisition of data; BS: acquisition of data, analysis and interpretation of data, critical revision of the manuscript for important intellectual content; JC: acquisition of data, analysis and interpretation of data.
Conflicts of interest The authors disclose no conflicts.
Funding Supported by National Institutes of Health grant R01DK100508 and startup funds from the Department of Molecular Biomedical Sciences and the College of Veterinary Medicine at NC State University.
© 2019 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.