Original ResearchZnT2-Mediated Zinc Import Into Paneth Cell Granules Is Necessary for Coordinated Secretion and Paneth Cell Function in Mice
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Keywords
Small Intestine
Zinc Transporter
Microbiota
Abbreviations used in this paper
CFU
colony forming unit
EPEC
enteropathogenic Escherichia coli
ER
endoplasmic reticulum
IF
immunofluorescent
IL
interleukin
IP
intraperitoneal
ko
knockout
LPS
lipopolysaccharide
NEC
necrotizing enterocolitis
OTU
organizational taxonomic unit
PBS
phosphate-buffered saline
PC
Paneth cell
PCR
polymerase chain reaction
TNF
tumor necrosis factor
wt
wild-type
ZIP
ZRT, IRT-like protein
Zn
zinc
ZnT
zinc transporter
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Conflicts of interest The authors disclose no conflicts.
Funding Supported by intramural support from the Academic Enrichment Fund (S.L.K.) and David L. Nahrwold Endowment (D.I.S.) of the Penn State Hershey Department of Surgery, and work at Juniata College was supported by a grant from the Howard Hughes Medical Institute through the Precollege and Undergraduate Science Education Program and a National Science Foundation award (DBI-1248096).
Copyright © 2016 The Authors. Published by Elsevier Inc.