Journal of Biological Chemistry
Volume 297, Issue 4, October 2021, 101128
JBC ReviewsNew strategies for targeting kinase networks in cancer
Under a Creative Commons license
open access
Keywords
cancer therapy
receptor tyrosine kinases
mitogen-activated protein kinase (MAPK)
drug resistance
cell signaling
combination therapy
targeted therapy
inhibitor
mathematical modeling
kinase network
Abbreviations
ABL1
Abelson tyrosine-protein kinase 1
ALK
anaplastic lymphoma kinase
BCL2
B-cell lymphoma 2
BCR
breakpoint cluster region
BRD4
bromodomain-containing protein
4CML
chronic myelogenous leukemia
DDR1
discoidin domain receptor tyrosine kinase 1
EGFR
epidermal growth factor receptor
GIST
gastrointestinal stromal tumor
HER2
human epidermal growth factor receptor 2
IGF1R
insulin-like growth factor 1 receptor
JAK/STAT
janus kinase/signal transducer and activator of transcription
MIB-MS
multiplexed inhibitor beads coupled with mass spectrometry
MEK/ERK
mitogen-activated kinase kinase/extracellular signal regulated kinase
mTOR
mammalian target of rapamycin
PD1
programmed cell death protein 1
PD-L1
programmed death-ligand 1
PI3K/AKT
phosphoinositide 3-kinase/protein kinase B
RKIP
Raf kinase inhibitory protein
TNBC
triple-negative breast cancer
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© 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.