Journal of Biological Chemistry
Volume 296, January–June 2021, 100470
Accelerated CommunicationGlucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and influenza virus
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open access
Keywords
glucosylceramide
sphingolipids
antiviral drugs
glucosylceramide synthase
COVID-19
SARS-CoV-2
Abbreviations
CC50
cytotoxicity concentration 50%
CPE
cytopathic effect
DENV
dengue virus
DMSO
dimethyl sulfoxide
DNJ
deoxynojirimycin
DsiRNA
Dicer-substrate siRNA
GCS
glucosylceramide synthase
GlcCer
glucosylceramide
GZ-161
GENZ-667161
GZ-346
Genz-123346
LSD
lysosomal storage disease
MDCK
Madin–Darby Canine Kidney
MOI
multiplicity of infection
NB-DNJ
N-butyl–DNJ
PR8
influenza virus A/PR/8/34 (H1N1)
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
SI
selective index
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Both authors contributed equally to this article.
© 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.