Trends in Immunology
Autoimmunity special issueNK cells: elusive players in autoimmunity
Section snippets
Natural killer (NK) cells
NK cells mediate early protection against viruses, kill cancer cells, rid the body of antibody-coated cells and secrete cytokines, predominantly interferon-γ (IFN-γ) [1]. NK cells are related developmentally to T cells [2] but differ from T cells in that they do not express one single variable receptor but rely on a multitude of germline-encoded receptors for their specificity 3, 4. In addition, NK cells are thymus-independent and do not require pre-immunization to act but are ready to go on
NK cells in autoimmune diseases – protective or pathogenic?
The studies that have been performed point towards both protective and disease-promoting effects of NK cells, depending on the disease model.
NK cells as adaptive multicompetent players in autoimmunity
It is clear from the specific studies outlined earlier that NK cells can be both protective and pathogenic in different disease models, and sometimes even in the same model, such as EAE 13, 14, 24 and diabetes 21, 29. Two aspects of NK-cell biology might provide explanations for these opposing effects. The first deals with the possible functional differences between NK cells at different anatomical localizations and the second with the adaptability, or flexibility, of effector responses in NK
Future work
Although the adaptive arms of immunity are known culprits in autoimmunity, future studies will probably show a similarly important role for innate cells, including NK cells, in these responses. Regarding NK cells, the current picture is complex and contains images of both disease-promoting and disease-preventing roles (Figure 1). Difficulties in understanding discrepancies in the role of NK cells in autoimmunity might lie in our incomplete understanding of the in vivo biology of NK cells, as
Acknowledgements
Work in our laboratory is supported by the Swedish Research Council, the Swedish Cancer Society, the Clas Groshinsky Memory Foundation, the Swedish Medical Doctor's Association, the Human Frontiers Science Foundation and the Swedish Foundation for Strategic Research. This work was performed within IRIS, a strategic research center sponsored by the Swedish Foundation for Strategic Research.
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