SurveyUnderstanding the mechanism of IL-1β secretion
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Gloria Lopez-Castejon is a Research Associate at the University of Manchester, UK. She completed her PhD at the University of Murcia, Spain in 2007 investigating the mechanisms of secretion of IL-1β in teleost fish. Since 2007 she has studied the contribution of macrophages to inflammation, and in particular the regulation of IL-1 production.
David Brough is a Wellcome Trust Career Development Research Fellow at the University of Manchester, UK. He completed his PhD at the University of Manchester in 2002 investigating the purinergic control of IL-1β secretion from microglia. Between 2002 and 2005 he worked as a postdoctoral research associate at the University of Cambridge investigating cell signalling mechanisms controlled by inositol lipids and soluble inositol phosphates. In 2005 he returned to Manchester, initially as a postdoc until 2008 when he was awarded his fellowship. His lab is focused on understanding the initiation of inflammation following injury, and how the key pro-inflammatory cytokine IL-1β is secreted from the cell.