Cell Metabolism
Volume 33, Issue 11, 2 November 2021, Pages 2108-2121
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Perspective
Nutrients in the fate of pluripotent stem cells

https://doi.org/10.1016/j.cmet.2021.09.013Get rights and content
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Summary

Pluripotent stem cells model certain features of early mammalian development ex vivo. Medium-supplied nutrients can influence self-renewal, lineage specification, and earliest differentiation of pluripotent stem cells. However, which specific nutrients support these distinct outcomes, and their mechanisms of action, remain under active investigation. Here, we evaluate the available data on nutrients and their metabolic conversion that influence pluripotent stem cell fates. We also discuss key questions open for investigation in this rapidly expanding area of increasing fundamental and practical importance.

Keywords

nutrients
metabolism
pluripotent stem cell
fate
development
differentiation

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These authors contributed equally