Cell Metabolism
Volume 26, Issue 2, 1 August 2017, Pages 301-309
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Review
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

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The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors.

Keywords

growth control
mTOR
mTORC1
amino acid sensing
nutrient sensing
amino acid sensors
Sestrins
Sestrin2
SLC38A9
CASTOR

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