Cell Host & Microbe
Volume 22, Issue 1, 12 July 2017, Pages 7-9
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War on Viruses: LC3 Recruits GTPases

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Interferon effector functions and autophagy are evolutionarily conserved arms of cell-autonomous immunity that restrict replication of intracellular pathogens. In this issue of Cell Host and Microbe, Biering et al., (2017) demonstrate how host cells co-opt sequential action of autophagy proteins and IFN-inducible GTPases to inhibit replication of positive-sense RNA viruses.

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