Cell Systems
Volume 7, Issue 3, 26 September 2018, Pages 347-350.e1
Journal home page for Cell Systems

Tool
Coral: Clear and Customizable Visualization of Human Kinome Data

https://doi.org/10.1016/j.cels.2018.07.001Get rights and content
Under an Elsevier user license
open archive

Highlights

  • Coral is a user-friendly web application for the visualization of human kinome data

  • Qualitative and quantitative data can be encoded in edge and node color and node size

  • Users can visualize the kinome in multiple forms, including tree and network views

  • Coral generates high-resolution vector figures fit for direct use in publications

Summary

Protein kinases represent one of the largest gene families in eukaryotes and play roles in a wide range of cell signaling processes and human diseases. Current tools for visualizing kinase data in the context of the human kinome superfamily are limited to encoding data through the addition of nodes to a low-resolution image of the kinome tree. We present Coral, a user-friendly interactive web application for visualizing both quantitative and qualitative data. Unlike previous tools, Coral can encode data in three features (node color, node size, and branch color), allows three modes of kinome visualization (the traditional kinome tree as well as radial and dynamic force networks), and generates high-resolution scalable vector graphics files suitable for publication without the need for refinement using graphics editing software. Due to its user-friendly, interactive, and highly customizable design, Coral is broadly applicable to high-throughput studies of the human kinome. The source code and web application are available at github.com/dphansti/CORAL and phanstiel-lab.med.unc.edu/Coral, respectively.

Keywords

kinase
kinome
data visualization

Cited by (0)

9

These authors contributed equally

10

Lead Contact