Cell
Volume 177, Issue 7, 13 June 2019, Pages 1682-1699
Journal home page for Cell

Review
Autophagy-Independent Functions of the Autophagy Machinery

https://doi.org/10.1016/j.cell.2019.05.026Get rights and content
Under an Elsevier user license
open archive

Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic entities. Over the past 2 decades, the molecular mechanisms underlying several variants of autophagy have been characterized in detail. Accumulating evidence suggests that most, if not all, components of the molecular machinery for autophagy also mediate autophagy-independent functions. Here, we discuss emerging data on the non-autophagic functions of autophagy-relevant proteins.

Keywords

ATG5
BECN1
LC3-associated phagocytosis
proliferation
regulated cell death
vesicular trafficking

Cited by (0)