Cell
Volume 152, Issue 6, 14 March 2013, Pages 1344-1354
Journal home page for Cell

Review
Chromatin Remodeling at DNA Double-Strand Breaks

https://doi.org/10.1016/j.cell.2013.02.011Get rights and content
Under an Elsevier user license
open archive

DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to ionizing radiation. The repair of DSBs involves both posttranslational modification of nucleosomes and concentration of DNA-repair proteins at the site of damage. Consequently, nucleosome packing and chromatin architecture surrounding the DSB may limit the ability of the DNA-damage response to access and repair the break. Here, we review early chromatin-based events that promote the formation of open, relaxed chromatin structures at DSBs and that allow the DNA-repair machinery to access the spatially confined region surrounding the DSB, thereby facilitating mammalian DSB repair.

Cited by (0)