Cell
Volume 146, Issue 3, 5 August 2011, Pages 353-358
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Essay
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

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Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs “talk” to each other using microRNA response elements (MREs) as letters of a new language. We propose that this “competing endogenous RNA” (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.

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Present address: Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA