Cell
Volume 143, Issue 1, 1 October 2010, Pages 27-29
Journal home page for Cell

Preview
How to Survive Aneuploidy

https://doi.org/10.1016/j.cell.2010.09.030Get rights and content
Under an Elsevier user license
open archive

Aneuploidy, or an abnormal number of chromosomes, adversely affects cell growth, but it is also linked with cancer and tumorigenesis. Now, Torres et al. (2010) help to resolve this paradox by demonstrating that aneuploid yeast cells can evolve mutations in the proteasome protein degradation pathway that alleviate imbalances in protein production and increase the cell's proliferative capacities.

Cited by (0)