Cell
Volume 140, Issue 5, 5 March 2010, Pages 601-605
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Essay
Membrane Curvature in Synaptic Vesicle Fusion and Beyond

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Recent evidence suggests that the Ca2+-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.

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