Cell
Volume 137, Issue 6, 12 June 2009, Pages 1001-1004
Journal home page for Cell

Minireview
p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

https://doi.org/10.1016/j.cell.2009.05.023Get rights and content
Under an Elsevier user license
open archive

The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-κB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.

Cited by (0)