Cancer Cell
Volume 19, Issue 6, 14 June 2011, Pages 728-739
ArticlePancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence
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Highlights
► Adult acinar cells are resistant to multiple oncogenic insults ► Limited bouts of pancreatitis cooperate with K-Ras to induce mPDAC in adult mice ► Pancreatitis abrogates senescence in low-grade PanINs ► Pancreatitis patients have senescent PanINs if treated with antiinflammatory drugs
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Present address: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
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