Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling
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Keywords
Ubiquitin
Innate immunity
TNF
TLR3
NOD1
LUBAC
Abbreviations
AMSH-LP
AMSH-like protein
λ-PPase
bacteriophage λ protein phosphatase
BMDM
bone marrow-derived macrophages
JNK
c-Jun N-terminal kinase
cIAP
cellular Inhibitor of Apoptosis
DUB
deubiquitylase
dsRNA
double-stranded RNA
GST
glutathione-S-transferase
HRP
horseradish peroxidase
IKK
IκB kinase
IL-1
interleukin-1
IL-1R
IL-1 receptor
IRAK
IL-1R-Associated Kinase
LUBAC
Linear UBiquitin Assembly Complex
K63-Ub
Lys63-linked ubiquitin
M-CSF
Macrophage Colony Stimulating Factor
M1-Ub
Met1-linked ubiquitin
MyD88
Myeloid Differentiation primary response gene 88
NEMO
NF-κB Essential Modifier
NOD
Nucleotide Oligomerisation Domain
PRRs
Pathogen Recognition Receptors
PNGase F
Protein Asparaginyl Glycosidase F
RIP
Receptor-Interacting Protein
TAK1
TGFβ-activated kinase 1
TAB
TAK1-binding protein
TRAF
TNF-Receptor-Associated Factor
TLR
Toll-Like Receptor
TRIF
TIR-domain-containing adapter-inducing interferon-β
TNFα
Tumour Necrosis Factor α
TNFR1
TNFα Receptor 1
TRADD
TNF-receptor associated death domain protein
Ub
Ubiquitin
USP
Ub-specific protease
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Joint First Authors.
© 2016 The Authors. Published by Elsevier Inc.