Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1833, Issue 1, January 2013, Pages 213-224
ReviewWhere the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)☆
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Highlights
► This review describes the discovery of the mitochondria-associated membrane (MAM). ► The MAM accommodates lipid metabolism, but also ER–mitochondria calcium signaling. ► Oxidoreductases (e.g. Ero1α) and chaperones (e.g. calnexin) regulate MAM signaling. ► Targeting to the MAM depends on redox, phosphorylation or palmitoylation. ► MAM tethers play important roles in neurodegenerative diseases.
Keywords
Endoplasmic reticulum (ER)
Mitochondria
Mitochondria-associated membrane (MAM)
Lipid metabolism
Calcium signaling
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This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology.
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