Original articleVisual Impairment and Blindness Due to Macular Diseases Globally: A Systematic Review and Meta-Analysis
Section snippets
Methods
We systematically reviewed articles published between January 1980 and January 2012, we primarily identified 14 908 relevant manuscripts out of which 243 articles of high-quality, population-based studies remained after application of rigorous selection criteria and review by an expert panel.10, 11 The study was approved by the ethics committee II of the Medical Faculty Mannheim of the University of Heidelberg. We used MEDLINE, Embase and the World Health Organization library information
Results
Of 32.4 million people who were blind and 191 million people who were vision impaired in 2010,9 2.1 million (95% uncertainty interval (UI): 1.9, 2.7) people were blind, and 6.0 million (95% UI: 5.2, 8.1) million were visually impaired due to macular diseases, worldwide (Table 1).
Between 1990 and 2010, the number of people blind due to macular diseases increased by 0.6 million people, or 36%, and the number of visually impaired people by 2.7 million people, or 81%. During the same period the
Discussion
In 2010, of 32.4 million blind and 191 million vision impaired people, 2.1 million people were blind, and 6.0 million were visually impaired due to macular diseases, excepting those of diabetic maculopathy. The age-standardized prevalence of blindness related to macular diseases worldwide in adults aged 50 years or older in 2010 was 0.1 %, and the prevalence of moderate to severe visual impairment was 0.2%. These figures complement the findings obtained in a recent meta-analysis by Wong and
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(A list of the Vision Loss Expert Group members appears at http://www.anglia.ac.uk/ruskin/en/home/microsites/veru/other_research_areas/global_burden_of_diseases.html.)