Trends in Genetics
Volume 13, Issue 12, December 1997, Pages 479-484
Journal home page for Trends in Genetics

Review
STAR, a gene family involved in signal transduction and activation of RNA

https://doi.org/10.1016/S0168-9525(97)01269-9Get rights and content

Abstract

A new subfamily of KH-domain-containing RNA-binding proteins is encoded by genes that are conserved from yeast to humans. Mutations with interesting developmental phenotypes have been identified in Caemorbabditis elegans, Drosophila and mouse. It is hypothesized that these bifunctional proteins provide a rich source of interesting molecular information about development and define a new cellular pathway that links signal transduction directly to RNA metabolism.

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