Human serum immunoglobulin concentrations: Prevalence of immunoglobulin deficiencies+

https://doi.org/10.1016/S0091-6749(75)80006-6Get rights and content

Classical antibody deficiency syndromes, such as sex-linked agammaglobulinemia, are rare and relatively homogeneous in presentation. In the present investigation an unselected group of 3,213 individuals from a community health study was examined in an attempt to estimate the prevalence of the commoner and largely unclassified examples of immunoglobulin deficiencies defined by the lower 2.5 per cent of the population. The prevalence of selective IgA deficiency (an isolated absence of IgA) was 0.097 per cent and that for selective IgM deficiency was 0.03 per cent. No isolated absence of IgG was found. In addition to these deficiency syndromes, concentrations of each of the immunoglobulins were found to be highly correlated to each other.

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    Supported by grants from the Institute of Gerontology of The University of Michigan and Wayne State University, The University of Michigan Medical School Fund for Computing, and the Michigan Chapter of The Arthritis Foundation. The Rackham Arthritis Research Unit is supported in part by a grant from the Horace H. Rackham School of Graduate Studies. The Tecumseh Community Health Study is supported by Program Project Grant HL 09814 from The National Heart and Lung Institute, National Institutes of Health.

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