Human serum immunoglobulin concentrations: Prevalence of immunoglobulin deficiencies+
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2022, Clinica Chimica ActaCitation Excerpt :Therefore, exploration of IgG glycosylation in the context of aging might help clarify the events that underlie the aging process at molecular level. With a concentration of about 10 mg/mL immunoglobulin G is among the most abundant proteins in the human serum [20,21]. It acts as a major effector molecule in the adaptive (acquired) humoral immune response [22] but also plays a paramount role in linking the adaptive and innate immune response [23,24].
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2020, Biosensors and BioelectronicsCitation Excerpt :We decided to perform the assay in human serum, as it is one of the most common applied samples in diagnosis (Trost, 2014). Besides, our LFA has been developed for the detection of general H-IgG (non-specific for a particular disease), which appears at a concentration ranging from 3 to 16 mg mL−1 in the human serum (Cassidy and Nordby, 1975). Given the fact that this concentration is far away from the linear range of the calibration curve (see Fig. 2A), we performed the validation assay by spiking different concentrations of H-IgG (0–103 ng mL−1) in immunoglobulins depleted human serum.
Laboratory Evaluation of Spasmodic Dysphonia
2020, Journal of VoiceCitation Excerpt :Both patients in our cohort were found to have elevated levels of ceruloplasmin rather than abnormally low levels. The combined incidence of immunoglobulin abnormalities (eg, IgG, IgM, IgE) was not statistically significant compared with normative data (20% vs. 12.3%, P = 0.11).22 It is also worth noting that the immunoglobulin abnormalities were heterogenous among patients, as three had low IgM titers, one had a high IgM titer.
Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG
2018, Journal of NeuroimmunologyCitation Excerpt :Glycosylation starts in the endoplasmic reticulum, then formed oligomannose structures are trimmed and addition of other sugars such as fucose, galactose and sialic acid happens in the Golgi apparatus (Stanley et al., 2009). Around 11 mg/ml of IgG are found in the serum of healthy human individuals (Cassidy and Nordby, 1975), whereas in cerebrospinal fluid (CSF) the concentration is only around 0.02 mg/ml (Ganrot and Laurell, 1974). IgG in CSF of healthy individuals is derived from the blood plasma and gains access to the ventricular and subarachnoid space across the blood brain barrier (Keir, 1986).
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Supported by grants from the Institute of Gerontology of The University of Michigan and Wayne State University, The University of Michigan Medical School Fund for Computing, and the Michigan Chapter of The Arthritis Foundation. The Rackham Arthritis Research Unit is supported in part by a grant from the Horace H. Rackham School of Graduate Studies. The Tecumseh Community Health Study is supported by Program Project Grant HL 09814 from The National Heart and Lung Institute, National Institutes of Health.