RNA and Protein Interactions Modulated by Protein Arginine Methylation

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Abstract

This review summarizes the current status of protein arginine N-methylation reactions. These covalent modifications of proteins are now recognized in a number of eukaryotic proteins and their functional significance is beginning to be understood. Genes that encode those methyltransferases specific for catalyzing the formation of asymmetric dimethylarginine have been identified. The enzyme modifies a number of generally nuclear or nucleolar proteins that interact with nucleic acids, particularly RNA. Postulated roles for these reactions include signal transduction, nuclear transport, or a direct modulation of nucleic acid interactions. A second methyltransferase activity that symmetrically dimethylates an arginine residue in myelin basic protein, a major component of the axon sheath, has also been characterized. However, a gene encoding this activity has not been identified to date and the cellular function for this methylation reaction has not been clearly established. From the analysis of the sequences surrounding known arginine methylation sites, we have determined consensus methyl-accepting sequences that may be useful in identifying novel substrates for these enzymes and may shed further light on their physiological role.

References (250)

  • S. Clarke

    Curr. Biol

    (1993)
  • P. Paolantonacci et al.

    Mol. Biochem. Parasitol

    (1986)
  • J.D. Gary et al.

    J. Biol. Chem.

    (1996)
  • W.J. Lin et al.

    J. Biol. Chem.

    (1996)
  • J. Nikawa et al.

    Gene

    (1996)
  • W.K. Paik et al.

    Biochem. Biophys. Res. Commun

    (1967)
  • W.K. Paik et al.

    J. Biol. Chem.

    (1968)
  • A.M. Kaye et al.

    Biochim. Biophys. Acta

    (1969)
  • Y. Kakimoto et al.

    J. Biol. Chem.

    (1970)
  • T. Nakajima et al.

    Biochim. Biophys. Acta

    (1971)
  • Y. Kakimoto

    Biochim. Biophys. Acta

    (1971)
  • E.H. Eylar et al.

    J. Biol. Chem.

    (1971)
  • S.W. Brostoff et al.

    Arch. Biochem. Biophys

    (1972)
  • G.E. Deibler et al.

    J. Biol. Chem.

    (1973)
  • P.R. Young et al.

    J. Chromatog

    (1987)
  • D. Gallwitz

    Arch. Biochem. Biophys

    (1971)
  • M.K. Paik et al.

    Int. J. Biochem

    (1991)
  • N. Sundarraj et al.

    Biochem. Biophys. Res. Commun

    (1973)
  • G.E. Deibler et al.

    J. Biol. Chem.

    (1973)
  • G.H. Park et al.

    Biochim. Biophys. Acta

    (1986)
  • S.K. Ghosh et al.

    J. Biol. Chem.

    (1988)
  • B. McCright et al.

    J. Biol. Chem.

    (1996)
  • A.L. Beyer et al.

    Cell

    (1977)
  • S.K. Ghosh et al.

    Biochim. Biophys. Acta

    (1990)
  • R. Rajpurohit et al.

    Biochim. Biophys. Acta

    (1992)
  • R. Rajpurohit et al.

    J. Biol. Chem.

    (1994)
  • A. Gupta et al.

    J. Biol. Chem.

    (1982)
  • P. Casellas et al.

    Biochim. Biophys. Acta

    (1978)
  • J.Z. Farooqui et al.

    J. Biol. Chem.

    (1985)
  • S. Fields et al.

    Trends Genet

    (1994)
  • B.S. Fletcher et al.

    J. Biol. Chem.

    (1991)
  • J.P. Rouault et al.

    Gene

    (1993)
  • S.F. Altschul et al.

    J. Mol. Biol

    (1990)
  • R.M. Kagan et al.

    Arch. Biochem. Biophys

    (1994)
  • G. Schluckebier et al.

    J. Mol. Biol

    (1995)
  • H. Xie et al.

    J. Biol. Chem.

    (1993)
  • H. Xie et al.

    J. Biol. Chem.

    (1994)
  • J. Najbauer et al.

    J. Biol. Chem.

    (1993)
  • J. Nikawa

    Gene

    (1994)
  • M.A. Lischwe et al.

    J. Biol. Chem.

    (1985)
  • C. Kamibayashi et al.

    J. Biol. Chem.

    (1994)
  • J. Najbauer et al.

    J. Biol. Chem.

    (1990)
  • M.E. Christensen et al.

    Biochem. Biophys. Res. Commun

    (1988)
  • A.W. Prestayko et al.

    FEBS Lett

    (1974)
  • R.A. Borer et al.

    Cell

    (1989)
  • M.A. Lischwe et al.

    J. Biol. Chem.

    (1982)
  • F. Cobianchi et al.

    J. Biol. Chem.

    (1986)
  • A. Kumar et al.

    J. Biol. Chem.

    (1986)
  • F. Cobianchi et al.

    J. Biol. Chem.

    (1988)
  • Y. Kakimoto et al.

    J. Neurochem

    (1975)
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