Morphometry of nuclear pore complexes in thyroid cells during hyperplasia and involution
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Nuclear pore complex maintenance and implications for age-related diseases
2022, Trends in Cell BiologyCitation Excerpt :Nevertheless, since all NPCs will be disassembled from the mother cells and equally reassembled in each daughter cell, the number of newly assembled NPCs during interphase is strictly regulated to maintain proper NPC amount after cell division. Dysregulation of the NPC number can cause severe outcomes, including cell identity loss and even tumorigenesis [33,34]. A recent study has shown that regulation of the interphase assembly exists when the Nup107–160 subcomplex is recruited to Pom121/Nup153.
Poring over chromosomes: mitotic nuclear pore complex segregation
2019, Current Opinion in Cell BiologyCitation Excerpt :NPC number per nucleus is controlled in a cell-type-specific and organism-specific manner, ranging from between a few hundred in yeast to a few thousands in mammalian cells [2,3]. Failure to control NPC numbers is associated with aggressive tumors and thyroid hyperplasia [4,5] but despite its importance, mechanisms regulating NPC number remain poorly understood. Once assembled into the NE, NPCs are stable structures that persist throughout interphase [6] and knockdown of proteins involved in NPC assembly results in an overall reduction in NPC numbers in yeast and humans [7,8].
Testosterone-induced changes in nuclear pore complex number of prostatic nuclei from castrated rats
1982, Journal of Ultrasructure ResearchQuantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe
2022, Life Science AllianceThe nuclear pore complex and mrna export in cancer
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