LETTERS to the EDITORFree β-hCG as first-trimester marker for fetal trisomy
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Maternal serum Down syndrome screening: free beta protein is a more effective marker than human chorionic gonadotropin
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(1988) Evaluation of an assay of the free beta subunit of choriogonadotropin and its potential value in screening for Down's syndrome
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Cited by (110)
Serum and ultrasound based screening tests for aneuploidy
2019, Perinatal GeneticsScreening for fetal growth restriction using fetal biometry combined with maternal biomarkers
2018, American Journal of Obstetrics and GynecologyCitation Excerpt :Studies of associations have been facilitated by the secondary analysis of first-trimester biomarkers derived from the placenta, which were evaluated in screening studies for aneuploidies. Low maternal circulating levels of pregnancy-associated plasma protein A (PAPP-A) and high concentrations of the free beta subunit of human chorionic gonadotropin (fβ-hCG) are both associated with the risk of Down syndrome.25 PAPP-A determines the availability of the insulin-like growth factors, key pregnancy growth hormones, as it is a protease that acts on insulin-like growth factor binding proteins.
The maternal plasma proteome changes as a function of gestational age in normal pregnancy: a longitudinal study
2017, American Journal of Obstetrics and GynecologyA historical and practical review of first trimester aneuploidy screening
2014, Seminars in Fetal and Neonatal MedicineCitation Excerpt :The clear advantages of a screening test in the first trimester included earlier reassurance to low risk patients, more time to consider options for diagnosis, and the possibility of earlier, safer termination in affected pregnancies. Spencer et al. [10] published their initial findings of free β-hCG as a marker for trisomies 21 and 18 in the first trimester and showed that the MoM value of free β-hCG in trisomy 21 was significantly greater and the median value in trisomy 18 was significantly lower than that in the unaffected controls. The idea of using free β-hCG was first proposed by Bogart et al. [11] who compared the ability of free versus total hCG to detect chromosomally abnormal fetuses in the second trimester.
Prenatal Screening for Neural Tube Defects and Aneuploidy
2013, Emery and Rimoin's Principles and Practice of Medical GeneticsFirst trimester screening for Down syndrome: Five years prospective experience
2011, Revue Sage - Femme