Cell
Volume 61, Issue 4, 18 May 1990, Pages 647-656
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Article
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

https://doi.org/10.1016/0092-8674(90)90476-UGet rights and content

Abstract

We previously identified two tyrosine protein kinase genes, designated trk and trkB, that code for putative neurogenic cell surface receptors. In this study, we report that the mouse trkB locus codes for at least two classes of receptor-like molecules. These trkB proteins, designated gp145trkB and gp95trkB, have identical extracellular and transmembrane domains, suggesting that they might recognize the same ligand(s). However, only gp145trkB contains a long cytoplasmic region, which includes a catalytic tyrosine protein kinase domain. trkB transcripts coding for this protein were observed in the cerebral cortex and the pyramidal cell layer of the hippocampus. In contrast, transcripts coding for the noncatalytic gp95trkB molecule were found in the ependymal linings of the cerebral ventricles and in the choroid plexus. These results illustrate that a tyrosine protein kinase locus can code for two structurally and functionally distinct cellular receptors.

References (26)

  • B.L.M. Hogan et al.

    Manipulating the Mouse Embryo

    (1986)
  • R. Klein et al.

    trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development

    EMBO J.

    (1989)
  • S.C. Kozma et al.

    Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences

    EMBO J.

    (1988)
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