Cell
Volume 60, Issue 5, 9 March 1990, Pages 755-765
ArticleInteraction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
References (62)
- et al.
Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen
J. Biol. Chem.
(1986) - et al.
Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes
Cell
(1987) - et al.
High affinity binding of an N-terminal myristolyated p60src peptide
J. Biol. Chem.
(1989) - et al.
A new technique for the assay of infectivity of human adenovirus 5 DNA
Virology
(1973) - et al.
T cell tolerence by clonal elimination in the thymus
Cell
(1987) - et al.
The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes
Cell
(1985) - et al.
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
Cell
(1985) Molecular biology and function of CD4 and CD8
Adv. Immunol.
(1989)Specific and saturable binding of pp60v-src to plasma membranes: evidence for a myristyl-src receptor
Cell
(1989)- et al.
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
Cell
(1988)
Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA
Cell
(1985)
Phosphorylation of the CD8 antigen on cytotoxic human T cells in response to phorbol myristate acetate or antigen presenting B cells
J. Immunol.
(1987)
Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule
Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma
J. Exp. Med.
(1988)
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex
Internalization of the human immunodeficiecy virus does not require the cytoplasmic domain of CD4
Nature
(1988)
Possible involvement of the T4 molecules in T cell recognition of class II HLA antigens: evidence from studies of CTL-target cell binding
J. Exp. Med.
(1984)
Influence of the major histocompatibility complex on positive thymic selection of VB17a+ T cells
Science
(1989)
Analysis of the site in CD4 that binds to the HIV envelope glycoprotein
J. Immunol.
(1990)
Myristic acid is attached to the transforming protein of Rous sarcoma virus during or immediately after synthesis and is present in both soluble and membrane-bound forms of the protein
Mol. Cell. Biol.
(1985)
A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6
Nature
(1986)
The src-family of protein tyrosine kinases
Interaction between CD4 and class II MHC molecules mediates cell adhesion
Synergism in the activation of human CD8 T cells by cross-linking the T-cell receptor complex with the CD8 differentiation antigen
Tat protein from human immunodeficiency virus forms a metal-linked dimer
Science
(1988)
Crystal structure of Cd, Zn metallothionein
Science
(1986)
NH2-terminal sequences of two src proteins that cause aberrant transformation
Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor
Nature
(1987)
Protein-tyrosine kinases
Annu. Rev. Biochem.
(1985)
Activators of protein kinase C induce dissociation of CD4, but not CD8, from p56lck
Science
(1989)
The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant
Mol. Cell. Biol.
(1988)
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Exploration of the therapeutic aspects of Lck: A kinase target in inflammatory mediated pathological conditions
2018, Biomedicine and PharmacotherapyCitation Excerpt :Thus, catalytic domain regulates various cellular processes like metabolism, transcription, cell cycle, cell movement, differentiation and apoptosis. The unique N-terminal mediates interaction with T cell surface co-receptors CD4 and CD8 by zinc coordination with conserved cysteine motifs present in both proteins [21]. Interestingly, Lck serves as an example where alteration in the site of phosphorylation results in alteration of physiological response [22].
Combination therapy of HIFα inhibitors and Treg depletion strengthen the anti-tumor immunity in mice
2023, European Journal of ImmunologyUnique roles of co-receptor-bound LCK in helper and cytotoxic T cells
2023, Nature ImmunologyThe kinase occupancy of T cell coreceptors reconsidered
2022, Proceedings of the National Academy of Sciences of the United States of America
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