Cell
ArticleLimited diversity of γδ antigen receptor genes of thy-1+ dendritic epidermal cells
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2020, Journal of Investigative DermatologyCitation Excerpt :Scattered in between the keratinocytes are epidermal sentinels of the immune system. In mice, the epidermal T cells are dominated by Vγ3+Vδ1+ (Garman nomenclature) (Garman et al., 1986) γδ T cells, termed dendritic epidermal T cells (DETCs) (Asarnow et al., 1988; Havran and Allison, 1988; Nielsen et al., 2017; Stingl et al., 1987), whereas in humans both γδ and αβ T cells are found in the epidermis (Toulon et al., 2009). It is known that T cells play important roles in ACD (Gocinski and Tigelaar, 1990; Scheper et al., 1983; Wang et al., 2000; Xu et al., 1996), and that DETCs can play both inflammatory and anti-inflammatory roles in response to contact allergens (Dieli et al., 1998, 1997; Nielsen et al., 2014; Sullivan et al., 1986; Welsh and Kripke, 1990).