Cell
ArticleRestricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy
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T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model
2019, Journal of NeuroimmunologyCitation Excerpt :In the MBP model, there is a strong overlap of the encephalitogenic epitopes between mice and humans (Sospedra and Martin, 2005). Moreover, V-gene restriction of myelin reactive T-cells leading to an oligoclonal T-cell repertoire has been especially found in MBP-induced mouse models (Acha-Orbea et al., 1988; Urban et al., 1988), a phenomenon that is also observed in MS patients (Hafler et al., 1996; Planas et al., 2018). Based on these findings, specific TCR directed therapies targeting the restricted repertoire were developed, although with little success (Killestein et al., 2002; Vandenbark et al., 2008; Wraith, 2009).
Treatment with tanshinone IIA suppresses disruption of the blood-brain barrier and reduces expression of adhesion molecules and chemokines in experimental autoimmune encephalomyelitis
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