Full paperFiber regeneration is not persistent in dystrophic (mdx) mouse skeletal muscle☆
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2020, Annals of AnatomyCitation Excerpt :Of particular interest in this context was the effect of this intervention on the masticatory muscles of dystrophic mice, in which at the age of approximately 100 days, the typical processes of muscle de- and regeneration should be mostly completed (Messina et al., 2006; Spassov et al., 2010, 2011). In mdx mice, massive muscle degeneration usually peaks between three and four weeks after birth, followed by functional regeneration by repair or replacement of degenerated muscle fibers at an age of 6–12 weeks, after which a stabilized condition is reached throughout the life span of the animals (DiMario et al., 1991; Turk et al., 2005). It is hypothesized that these newly formed or repaired muscle fibers are similar to those of the pre-degeneration phase and can better adapt to the lack of dystrophin through remodelling of muscle structure and fiber composition (Turk et al., 2005).
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This work was supported by research grants from the National Institutes of Health, the Muscular Dystrophy Association, and the Association Francaises Contre Les Myopathies.