Biochemical and Biophysical Research Communications
Metabolism of lysine in rat liver
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2015, Oral OncologyCitation Excerpt :Pipecolinic acid (piperidine-2-carboxylic acid, PA) concentrations were higher in the saliva samples obtained from OSCC patients at stages I–II compared with the samples from healthy subjects [30]. This metabolite is a cyclic amino acid that is produced during lysine degradation [45,46]. PA has been previously suggested as a possible biomarker for peroxisomal disorders, hepatic encephalopathy, and pyridoxine-dependent seizures, an autosomal recessive epileptic encephalopathy [47].
Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method
2015, Clinica Chimica ActaCitation Excerpt :Pipecolic acid (PA: piperidine-2-carboxylic acid) is a cyclic secondary imino acid including d- and l-enantiomers. It derives from one of the two pathways of lysine metabolism, merging at the level of α-aminoadipic acid semialdehyde (AASA) [1,2,3]. In the brain, the conversion of lysine to acetoacetyl CoA is predominant via l-pipecolic acid, while in the liver and in most other vertebrate tissues, lysine is metabolized via saccharopine.
Hyperpipecolic acidaemia: A diagnostic tool for peroxisomal disorders
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