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Valinomycin acts as a channel in ultrathin lipid membranes

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Abstract

When the thickness of monolayer membranes formed by bolaform archaeal lipids is reduced to the approximate length of two valinomycin molecules, the zero-current conductance does not show any more a linear dependence on valinomycin concentration; instead, a quadratic behaviour is observed. This suggests that a dimer permeation pore is formed and therefore the conduction mechanism changes from carrier to channel.

Keywords

Valinomycin
Ultrathin lipid membrane
Bolaform archaeal lipid
Conduction channel
Permeation

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