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Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

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Abstract

Aβ oligomers cause a collection of molecular events associated with memory loss in Alzheimer’s disease, centering on disrupting the maintenance of synapse structure and function. In this brief review of the synaptotoxic effects of Aβ oligomers, we focus on the neuronal properties governing oligomer targeting and toxicity—especially with respect to binding sites and mechanisms of binding. We also discuss ways in which mechanistic insights from other diseases offer clues in the pursuit of the molecular basis of Alzheimer’s disease.

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Authors and Affiliations

  1. Department of Neurobiology and Physiology, Northwestern University, Evanston, IL, 60208, USA

    Kyle C. Wilcox, Pascale N. Lacor, Jason Pitt & William L. Klein

  2. O.T. Hogan Biological Sciences 4-160, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA

    William L. Klein

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  1. Kyle C. Wilcox
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  2. Pascale N. Lacor
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  3. Jason Pitt
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  4. William L. Klein
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Correspondence to Kyle C. Wilcox or William L. Klein.

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Wilcox, K.C., Lacor, P.N., Pitt, J. et al. Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease. Cell Mol Neurobiol 31, 939–948 (2011). https://doi.org/10.1007/s10571-011-9691-4

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  • DOI: https://doi.org/10.1007/s10571-011-9691-4

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