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Wnts and the hallmarks of cancer

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Abstract

Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in cancers have been extensively investigated. Activation of this evolutionarily conserved pathway promotes cancer development via diverse mechanisms. Cancer is a complex disease and one outstanding conceptual framework for understanding its biology is the “Hallmarks of Cancer”. In this review, we focus on the involvement of Wnt signaling in the ten hallmarks of human cancer. These widespread roles of Wnt signaling in human cancers highlight the importance and feasibility of targeting this signaling pathway for cancer treatment.

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Acknowledgments

We gratefully acknowledge the assistance of Nakeisha Tan for the illustrations.

Funding

The authors received support from the Singapore Ministry of Health’s National Medical Research Council Open Fund–Independent Research grant NMRC/OFIRG/0055/2017 (to Babita Madan) and the STAR Award Program MOH-000155 (to David Virshup).

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  1. Zheng Zhong and Jia Yu contributed equally to this work.

Authors and Affiliations

  1. Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore

    Zheng Zhong, Jia Yu, David M. Virshup & Babita Madan

  2. Department of Pediatrics, Duke University School of Medicine, Durham, NC, 27710, USA

    David M. Virshup

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  1. Zheng Zhong
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Zhong, Z., Yu, J., Virshup, D.M. et al. Wnts and the hallmarks of cancer. Cancer Metastasis Rev 39, 625–645 (2020). https://doi.org/10.1007/s10555-020-09887-6

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