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An updated view on the structure and function of PYRIN domains

  • The Domains of Apoptosis and Inflammation
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Abstract

The PYRIN domain (PYD) is a protein–protein interaction domain, which belongs to the death domain fold (DDF) superfamily. It is best known for its signaling function in innate immune responses and particularly in the assembly of inflammasomes, which are large protein complexes that allow the induced proximity-mediated activation of caspase-1 and subsequently the release of pro-inflammatory cytokines. The molecular mechanism of inflammasome assembly was only recently elucidated and specifically requires PYD oligomerization. Here we discuss the recent advances in our understanding of PYD signaling and its regulation by PYD-only proteins.

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Acknowledgments

This work was supported by the National Institutes of Health (GM071723, AI099009 and AR064349 to C.S., and AR057532 to A.D.) and the American Heart Association (12GRNT12080035 to C.S).

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA

    Lan Hoang Chu, Anu Gangopadhyay, Andrea Dorfleutner & Christian Stehlik

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  1. Lan Hoang Chu
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  2. Anu Gangopadhyay
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  3. Andrea Dorfleutner
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  4. Christian Stehlik
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Correspondence to Andrea Dorfleutner or Christian Stehlik.

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Lan Hoang Chu and Anu Gangopadhyay have contributed equally to this work.

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Chu, L.H., Gangopadhyay, A., Dorfleutner, A. et al. An updated view on the structure and function of PYRIN domains. Apoptosis 20, 157–173 (2015). https://doi.org/10.1007/s10495-014-1065-1

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