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Transient receptor potential channelopathies

  • Molecular and Genomic Physiology
  • Published:
Pflügers Archiv - European Journal of Physiology Aims and scope Submit manuscript

Abstract

In the past years, several hereditary diseases caused by defects in transient receptor potential channels (TRP) genes have been described. This review summarizes our current knowledge about TRP channelopathies and their possible pathomechanisms. Based on available genetic indications, we will also describe several putative pathological conditions in which (mal)function of TRP channels could be anticipated.

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Acknowledgments

We thank all members of our laboratory for helpful discussions. This work was supported by grants from the Belgian Ministry for Science Policy (Interuniversity Attraction Pole IUAP P6/28), the Research Foundation-Flanders (G.0172.03 and G.0565.07), and the Research Council of the KU Leuven (GOA 2004/07and EF/95/010)

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Nilius, B., Owsianik, G. Transient receptor potential channelopathies. Pflugers Arch - Eur J Physiol 460, 437–450 (2010). https://doi.org/10.1007/s00424-010-0788-2

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