Abstract
In cells, microtubules (MTs) are nucleated at MT-organizing centers (MTOCs). The centrosome-based MTOCs organize radial MT arrays, which are often not optimal for polarized trafficking. A recently discovered subset of non-centrosomal MTs nucleated at the Golgi has proven to be indispensable for the Golgi organization, post-Golgi trafficking and cell polarity. Here, we summarize the history of this discovery, known molecular prerequisites of MT nucleation at the Golgi and unique functions of Golgi-derived MTs.
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Acknowledgments
We thank Drs. V. Magidson and A. Khodjakov (Wadsworth Center, Albany, NY) for the permission to use images obtained from our collaboration and presented in Fig. 1. This work was supported by National Institutes of Health grant R01-GM078373 (to I.K.).
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Zhu, X., Kaverina, I. Golgi as an MTOC: making microtubules for its own good. Histochem Cell Biol 140, 361–367 (2013). https://doi.org/10.1007/s00418-013-1119-4
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DOI: https://doi.org/10.1007/s00418-013-1119-4