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Partners and post-translational modifications of nuclear lamins

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Abstract

Nuclear intermediate filament networks formed by A- and B-type lamins are major components of the nucleoskeleton that are required for nuclear structure and function, with many links to human physiology. Mutations in lamins cause diverse human diseases (‘laminopathies’). At least 54 partners interact with human A-type lamins directly or indirectly. The less studied human lamins B1 and B2 have 23 and seven reported partners, respectively. These interactions are likely to be regulated at least in part by lamin post-translational modifications. This review summarizes the binding partners and post-translational modifications of human lamins and discusses their known or potential implications for lamin function.

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Acknowledgments

We thank Michael J. Matunis, Gerald W. Hart and Jason M. Berk for insightful discussions and comments on the manuscript. We apologize to authors whose work could not be cited here due to space limitations. We gratefully acknowledge support from the NIH (RO1 048646 to K.L.W.).

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  1. Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Dan N. Simon & Katherine L. Wilson

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Correspondence to Katherine L. Wilson.

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Communicated by Erich Nigg

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Simon, D.N., Wilson, K.L. Partners and post-translational modifications of nuclear lamins. Chromosoma 122, 13–31 (2013). https://doi.org/10.1007/s00412-013-0399-8

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