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Autotaxin

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Abstract

Autotaxin is a protein of approximately 900 amino acids discovered in the early 1990s. Over the past 15 years, a strong association between cancer cells and autotaxin production has been observed. Recent publications indicate that autotaxin and the capacity of cancer to metastasise are intimately linked. The discovery of new molecular targets in pharmacology is a mixture of pure luck, hard work and industrial strategy. Despite a crucial and desperate need for new therapeutic tools, many targets are approached in oncology, but only a few are validated and end up at the patient bed. Outside the busy domain of kinases, few targets have been discovered that can be useful in treating cancer, particularly metastatic processes. The fortuitous relationship between autotaxin and lysophosphatidic acid renders the results of observations made in the diabetes/obesity context considerably important. The literature provides observations that may aid in redesigning experiments to validate autotaxin as a potential oncology target.

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Abbreviations

lpa:

Lysophosphatidic acid

lpc:

Lysophosphatidylcholine

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Acknowledgments

The authors are indebted to Prof. Max Lafontan for initiating a fruitful collaboration in which Prof. Philippe Valet and Dr. Jean-Sébastien Saulnier-Blache were involved as key players, and to Prof. Dave Brindley for hours of enthusiastic conversations on the future of ATX. Many of our colleagues should also be thanked for their many suggestions and experimental works, among which are Dr. Gordon C. Tucker, Dr. Alex Cordi, Dr. Amine Abina and his colleagues at NoKad, Dr. Kader Thiam and his colleagues at genOway, Dr. Michel Lonchampt, Dr. Francis Cogé, Dr. Adeline Giganti, Dr. Jean-Pierre Galizzi, Dr. Marianne Rodriguez, Dr. Arnaud Gohier, Dr. Benjamin Fould, Dr. Karine Clément, Dr. Olivier Peyruchaud, Ms. Anne Try, Sophie-Pénélope Guenin, Natacha Moulharat, Monique Beucher, Annie Genton, Isabelle Naime, Sophie Letrou, Caroline Loew, Marion Balanger and Camille Gaubert. The help of Drs. Brian Lockhart and Nolwen Guigal-Stephan on the microarrays and of Mrs. Nicole Taimiot for her secretarial assistance is also fully appreciated.

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  1. Pharmacologie Moléculaire et Cellulaire, Institut de Recherches SERVIER, 125 chemin de Ronde, 78290, Croissy-sur-Seine, France

    Jean A. Boutin & Gilles Ferry

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  1. Jean A. Boutin
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Boutin, J.A., Ferry, G. Autotaxin. Cell. Mol. Life Sci. 66, 3009–3021 (2009). https://doi.org/10.1007/s00018-009-0056-9

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