Abstract.
The HMG-box domain of ~75 amino acid residues was originally identified as the domain that mediates the DNA-binding of chromatin-associated high-mobility group (HMG) proteins of the HMGB type. In the last few years, HMG-box domains have been found in various DNA-binding proteins including transcription factors and subunits of chromatin-remodeling complexes. HMG-box domains mediate either non-sequence-specific (e.g., HMGB-type proteins) or sequence-specific (e.g., transcription factors) DNA binding. Both types of HMG-box domains bind non-B-type DNA structures (bent, kinked and unwound) with high affinity. In addition, HMG-box domains are involved in a variety of protein-protein interactions. Here, we have examined the human and plant genomes for genes encoding HMG-box domains. Compared to plants, human cells contain a larger variety of HMG-box proteins. Whereas in humans transcription factors are the most divergent group of HMG-box proteins, in plants the chromosomal HMGB-type proteins are most variable.
Similar content being viewed by others
Author information
Authors and Affiliations
Corresponding authors
Additional information
Received 30 March 2007; received after revision 29 May 2007; accepted 18 June 2007
Rights and permissions
About this article
Cite this article
Štros, M., Launholt, D. & Grasser, K.D. The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins. Cell. Mol. Life Sci. 64, 2590 (2007). https://doi.org/10.1007/s00018-007-7162-3
Published:
DOI: https://doi.org/10.1007/s00018-007-7162-3