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Genetic Engineering pp 131–147Cite as

Investigational Approaches for Studying the Structures and Biological Functions of Myeloid Antimicrobial Peptides

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Part of the book series: Genetic Engineering: Principles and Methods ((GEPM,volume 15))

Abstract

Macrophages and neutrophils are phagocytic leukocytes of myeloid lineage, arising from hematopoietic precursors in the bone marrow. Neutrophils are short-lived cells which are terminally differentiated as they enter the circulation, whereas macrophages derive from circulating monocytes which mature into specialized cells in various tissues including lung, liver and skin. The phagocytic and microbicidal functions of neutrophils and macrophages provide an essential component of the host’s defense against colonization by a diverse spectrum of potential pathogens.

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Author information

Authors and Affiliations

  1. Departments of Pathology and Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, CA, 92717, USA

    Michael E. Selsted

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  1. Michael E. Selsted
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Editor information

Editors and Affiliations

  1. Brookhaven National Laboratory, Upton, New York, USA

    Jane K. Setlow

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© 1993 Springer Science+Business Media New York

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Selsted, M.E. (1993). Investigational Approaches for Studying the Structures and Biological Functions of Myeloid Antimicrobial Peptides. In: Setlow, J.K. (eds) Genetic Engineering. Genetic Engineering: Principles and Methods, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1666-2_6

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  • DOI: https://doi.org/10.1007/978-1-4899-1666-2_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1668-6

  • Online ISBN: 978-1-4899-1666-2

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