Abstract
Although there is a large literature describing age-related physiological changes at the cell, tissue, organ, and organism level, fundamental questions about the aging process remain unanswered. In fact, it can be said that the experimental design required to answer them is in many ways obscure. For example, we still need answers to such questions as: (1) is aging intrinsic or extrinsic to the organism; (2) is aging intrinsic to an individual cell or an integrated function; (3) are there mechanisms which control the rate of aging; (4) is there a kind of pacemaker cell that signals the rest of the cells to degenerate and die, or does each cell have its own clock-like machinery by which aging proceeds; and (5) in either case, would such a clock mechanism be contained in the nucleus or in the cytoplasm? Definitive answers to all these questions must precede elucidation of the biology of aging.
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Bibliography
Balin, A., D. B. P. Goodman, H. Rasmussen, and V. J. Cristofalo. 1977. The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro. Journal of Cell Biology 74: 58–67.
Cristofalo, V. J. 1972. Animal cell cultures as a model system for the study of aging. Advances in Gerontological Research 4: 45–79.
Cristofalo, V. J. 1975. Hydrocortisone as a modulator of cell division and population life span. Pages 57–79 in V. J. Cristofalo, J. Roberts, and R. C. Adelman, eds. Explorations in aging. Plenum Press, New York.
Dell’Orco, R. T., J. G. Mertens, and P. F. Kruse, Jr., 1973. Doubling potential, calendar time, and senescence of human diploid cells in culture. Experimental Cell Research 77: 356–360.
Hayflick, L. 1965. The limited in vitro lifetime of human diploid cell strains. Experimental Cell Research 37: 614–636.
Hayflick, L., and P. S. Moorhead. 1961. The serial cultivation of human diploid cell strains. Experimental Cell Research 25: 585–621.
Martin, G. M., C. Sprague, and C. J. Epstein. 1970. Replicative life-span of cultivated human cells. Laboratory Investigation 23: 86–92.
Norwood, T. H., W. R. Pendergrass, and G. M. Martin. 1975. Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential. Journal of Cell Biology 64: 551–556.
Schneider, E. L., and Y. Mitsui. 1976. The relationship between in vitro cellular aging and in vivo human age. Proceedings of the National Academy of Sciences of the USA 73: 3584–3588.
Wright, W. E., and L. Hayflick. 1975. Nuclear control of cellular aging demonstrated by hybridization of anucleate and whole cultured normal human fibroblasts. Experimental Cell Research 96: 113–121.
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© 1978 Plenum Press, New York
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Cristofalo, V.J., Stanulis, B.M. (1978). Cell Aging: A Model System Approach. In: Behnke, J.A., Finch, C.E., Moment, G.B. (eds) The Biology of Aging. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3994-6_2
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DOI: https://doi.org/10.1007/978-1-4613-3994-6_2
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