Regular Article‘Putting the squeeze’ on the tight junction: understanding cytoskeletal regulation
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Role of Bifidobacterium in Modulating the Intestinal Epithelial Tight Junction Barrier: Current Knowledge and Perspectives
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2022, Journal of Controlled ReleaseCitation Excerpt :However, in certain cases, decrease in the integrity of tight junctions can lead to enlargement of the intercellular space, and in turn allow for the passage of particles. This enhanced permeation through tight junctional modulation has been observed to occur spontaneously when particles interact with epithelial cells as this may lead to decrease of the epithelial barrier integrity as shown in several in vivo studies [39,158–160]. The Caco-2 cells model was also used to explore the involvement of intercellular junctions in particle transport [158,159].
Target specific tight junction modulators
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