Regular ArticleGenomic Structure and Chromosomal Localization ofTCEAL1,a Human Gene Encoding the Nuclear Phosphoprotein p21/SIIR☆
References (12)
- et al.
Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 → p21.3
Genomics
(1996) - et al.
A physical map of 15 loci on human chromosome 5q23–q33 by two-color fluorescencein situ
Genomics
(1993) - et al.
Acis
J. Biol. Chem.
(1995) - et al.
The Ser3637
J. Biol. Chem.
(1995) - et al.
PAK3
Nat. Genet.
(1998)
Cited by (15)
TCEAL1 loss-of-function results in an X-linked dominant neurodevelopmental syndrome and drives the neurological disease trait in Xq22.2 deletions
2022, American Journal of Human GeneticsCitation Excerpt :TCEAL1 (transcription elongation factor A-like 1 [MIM: 300237]) is a single coding-exon gene that encodes a 21-kDa nuclear phosphoprotein, referred to as TCEAL1 (or p21/SIIR). The encoded protein is related to the S-II class of transcription elongation factors as it consists of three main functional domains along its length of 157 amino acids (aa), an arginine/serine (RS) domain, a zinc-finger-like (ZnF-L) domain, and a helix-turn-helix (HTH) domain, and has a predicted RNA polymerase II binding site.5,6,7 Previous knockout functional studies of the different domains of TCEAL1 in the context of the Rous sarcoma virus were conducted in transfected COS-1 cells where it was shown that loss of function (LoF) of the C-terminal domain of TCEAL1, RS, and the middle domain, ZnF-L, lead to down-regulation of the promoter activity of the virus; whereas LoF of the N-terminal domain, HTH, had minimal effects on the promoter activity of the virus.6
hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression
2021, Molecular Medicine ReportsIn vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer
2020, Life Science Alliance
- ☆
Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. AF095906.
- 1
To whom correspondence should be addressed. Telephone: (732) 235-5311. Fax: (732) 235-5318. E-mail:[email protected].