Immunology
Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infectionA soluble ACE2 protein bioengineered to have extended duration of action and enhanced affinity for SARS-CoV-2 provides markedly improved survival and organ protection when administered intranasally. Reducing brain SARS-CoV-2 titers is an important determinant of therapeutic efficacy.
Correction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential biomarker and therapeutic target of pulmonary fibrosis.
An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicityThis work describes how a mutation affecting mitochondrial metabolism in a sarcoma model induces protective immunity against the tumor and how this result might be relevant for sarcoma patients.
FBXO11 governs macrophage cell death and inflammation in response to bacterial toxinsFBXO11 regulates the expression of the complement receptor C5aR1 and the inflammatory cytokine IL-1β, affecting how macrophages respond to Staphylococcus aureus pore–forming toxins.
Potency assessment of IFNγ-producing SARS-CoV-2-specific T cells from COVID-19 convalescent subjectsSARS-CoV-2-specific T-cells from convalescent donors present phenotypical and functional characteristics that make them a suitable candidate for a future development of an advanced cellular therapy.
Defibrotide impact on the acute GVHD disease incidence in pediatric hematopoietic stem cell transplant recipientsThe prophylactic use of defibrotide in pediatric HSCT recipients significantly reduces the incidence and severity of acute GVHD, with a modification of cytokine pattern, both strongly coherent with the protective drug’s action.
Plasma proteome dynamics of COVID-19 severity learnt by a graph convolutional network of multi-scale topologyWe used a graph convolutional network to model the plasma proteome of 384 COVID-19 patients. The model incorporates clinical data and is able to predict severity. We identified the proteins that shifted most in expression depending on severity.
ICOS costimulation is indispensable for the differentiation of T follicular regulatory cellsICOS signaling promotes T follicular regulatory cell differentiation during germinal center reaction safeguarding against autoantibody production.
The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growthThe FERM domain protein iTAP/Frmd8, which binds to and stabilizes the ADAM17/iRhom sheddase complex at the cell surface, is a regulator of inflammation, epithelial homeostasis, and tumor growth in vivo.
Linear ubiquitination induces NEMO phase separation to activate NF-κB signalingThe E3 ubiquitin ligase HOIP generates linear ubiquitin chains that promote liquid-liquid phase separation of NEMO in vitro, which correlates with the formation of NEMO condensates and IKK complex activation in cells.