Immunology
- Lung macrophages utilize unique cathepsin K–dependent phagosomal machinery to degrade intracellular collagen
This study provides a comprehensive map of how peritoneal, lung, and brain tissue environment shapes phagosomal composition, revealing cathepsin K as the main peptidase in the intracellular destruction of collagen, which is mainly active in lung macrophages.
- Lineage tracing reveals fate bias and transcriptional memory in human B cells
We combined lineage tracing and single-cell transcriptomics to quantify the extent of cell-intrinsic fate bias in human B cells.
- Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19
Severe COVID-19 is associated with alterations to the neutrophil compartment with circulating hyperactive immature neutrophils and a maintenance of CXCR2 expression.
- SLAMF6 compartmentalization enhances T cell functions
After stimulation, the T cell co-receptor SLAMF6 colocalizes with the TCR–CD3 complex to enhance T cell activation. Targeting SLAMF6 localization and function with bispecific antibodies is a novel mechanism with potential therapeutic translation.
- Inflammasome is a central player in B cell development and homing
Whereas the inflammasome is known to be a key player in innate immunity, this study shows that NLRP3 is essential for egress/mobilization of B cells from the bone marrow to secondary lymphoid organs.
- Direct CD32 T-cell cytotoxicity: implications for breast cancer prognosis and treatment
CD32-chimeric receptor T cell identifies CD32 cell surface ligand(s), on breast cancer (BC) cells, leading to BC cell elimination in vitro and in vivo and allowing detection of genes prognostically relevant.
- Autoimmune RNA dysregulation and seizures: therapeutic prospects in neuropsychiatric lupus
Lupus autoantibodies directed at neuroregulatory BC200 RNA cause seizure susceptibility in mice, but sequestration with antigen prevents seizures, indicating utility in therapeutic interventions.
- Correction: The intracellular pathogen Francisella escapes from adaptive immunity by metabolic adaptation
This study shows that this metabolic adaptation allows the intracellular bacterial pathogen Francisella tularensis to escape recognition by the host adaptive immunity.
- Methionine uptake via the SLC43A2 transporter is essential for regulatory T-cell survival
Regulatory T cells survive after IL-2 withdrawal by taking up and using methionine through the SLC43A2 transporter in a Notch1-dependent manner.
- Cross talk between glucose metabolism and immunosuppression in IFN-γ–primed mesenchymal stem cells
This study reveals a novel relationship between mesenchymal stem cell immunomodulation and metabolism and provides a new strategy to improve their therapeutic efficacy in inflammatory diseases.