Immunology
SHIP1 deficiency causes inflammation-dependent retardation in skeletal growthSHIP1 plays a cell-intrinsic role in osteoclast function and development, yet skeletal growth retardation in SHIP1-deficient mice is dependent on lymphocyte-induced inflammation.
Breast implant surface topography triggers a chronic-like inflammatory responseThis study explores the impact of breast implant surface topographies on immune responses, using analyses of periprosthetic fluids and in vitro cultures on model surface replicas, revealing that macrotextured implants significantly induce chronic-like inflammatory reactions.
Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model miceThis work shows that the CBX3, atypically expressed on the mesangial cell, is a target of IgA auto-Abs in IgA nephropathy model mice and patients. Such IgA auto-Abs are induced by oral bacteria in mice.
Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individualsThis study highlights the resilience of the gut microbiome to host immune changes triggered by COVID-19 vaccination and suggest minimal, if any, impact on microbiome-mediated processes.
Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infectionKnockdown of miR-126 increases susceptibility to mycobacterial infection which can be independently reversed by targeting Tsc1/mTOR or ccr2 implicating macrophage function.
Targeting circulating labile heme as a defense strategy against malariaMalaria remains a major cause of human morbidity and mortality. Circulating labile heme is an independent risk factor for severe P. falciparum malaria, suggesting that labile heme may be a therapeutic target against severe malaria.
NeoMUST: an accurate and efficient multi-task learning model for neoantigen presentationNeoMUST, a multi-task learning model, efficiently predicts neoantigen presentation via MHC-I molecules, rivaling existing algorithms with significantly shorter training time. Its GitHub repository offers free access for advancing cancer immunotherapy development.
Reduced myeloid commitment and increased uptake by macrophages of stem cell–derived HPS2 neutrophilsOur current work uses iPSC-derived neutrophils to unveil novel reasons for the neutropenia found in HPS2 patients. HPS2 iPSC-derived neutrophils have lower myeloid commitment, and are actively phagocytosed by macrophages present in the iPSC cultures or healthy donor macrophages.
Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancerCRISPR/Cas9 screening identifies the gene C22orf46 to counteract pro-apoptotic signals provided by T cells or anti-neoplastic drugs and contributes to tumorigenesis.
Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitorsTwo anti-PD-1 antibodies bind to distinct glycoforms of PD-1 found on cells or in blood, highlighting the potential of target glycoprofiling in the development of differentiated therapeutics.