Immunology
Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infectionKnockdown of miR-126 increases susceptibility to mycobacterial infection which can be independently reversed by targeting Tsc1/mTOR or ccr2 implicating macrophage function.
Targeting circulating labile heme as a defense strategy against malariaMalaria remains a major cause of human morbidity and mortality. Circulating labile heme is an independent risk factor for severe P. falciparum malaria, suggesting that labile heme may be a therapeutic target against severe malaria.
NeoMUST: an accurate and efficient multi-task learning model for neoantigen presentationNeoMUST, a multi-task learning model, efficiently predicts neoantigen presentation via MHC-I molecules, rivaling existing algorithms with significantly shorter training time. Its GitHub repository offers free access for advancing cancer immunotherapy development.
Reduced myeloid commitment and increased uptake by macrophages of stem cell–derived HPS2 neutrophilsOur current work uses iPSC-derived neutrophils to unveil novel reasons for the neutropenia found in HPS2 patients. HPS2 iPSC-derived neutrophils have lower myeloid commitment, and are actively phagocytosed by macrophages present in the iPSC cultures or healthy donor macrophages.
Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancerCRISPR/Cas9 screening identifies the gene C22orf46 to counteract pro-apoptotic signals provided by T cells or anti-neoplastic drugs and contributes to tumorigenesis.
Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitorsTwo anti-PD-1 antibodies bind to distinct glycoforms of PD-1 found on cells or in blood, highlighting the potential of target glycoprofiling in the development of differentiated therapeutics.
2′,3′ cyclic nucleotide 3′ phosphodiesterase 1 functional isoform antagonizes HIV-1 particle assemblyCNP1, not CNP2, is the primary isoform inhibiting HIV-1, highlighting posttranslational regulation in CNP antiviral role.
A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cellsThis work describes a high-throughput cellular assay specifically designed to study the understudied inhibitory signalling pathway in T cells.
RNA helicase EIF4A1-mediated translation is essential for the GC responseConditional mouse knock-out models show that EIF4A1, but not its cofactors EIF4B or EIF4H, is essential in B cells for their development, the GC response, and increased translation after activation.
FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon responseIKKβ-mediated phosphorylation of FAT10 dampens the antiviral type I interferon response by stabilizing OTUB1.