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Immunology

  • Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
    Open Access
    Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis

    Robert Brenig, Oltin T Pop, Evangelos Triantafyllou, Anne Geng, Arjuna Singanayagam, Christian Perez-Shibayama, Lenka Besse, Jovana Cupovic, Patrizia Künzler, Tuyana Boldanova, Stephan Brand, David Semela, François HT Duong, Christopher J Weston, Burkhard Ludewig, Markus H Heim, Julia Wendon, Charalambos G Antoniades, Christine Bernsmeier

    Robert Brenig ... Christine Bernsmeier

    Published 10 December 2019

    Immune dysfunction determines morbidity and mortality in liver cirrhosis. Distinct AXL-expressing circulating monocytes, which regulate antimicrobial responses, expand with progression of the disease.

  • Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt<sup>+</sup> T cells
    Open Access
    Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells

    Mari Tenno, Alicia Yoke Wei Wong, Mika Ikegaya, Eiji Miyauchi, Wooseok Seo, Peter See, Tamotsu Kato, Takashi Taida, Michiko Ohno-Oishi, Hiroshi Ohno, Hideyuki Yoshida, Florent Ginhoux, Ichiro Taniuchi

    Mari Tenno ... Ichiro Taniuchi

    Published 9 December 2019

    Loss of Runx/Cbfβ complexes during DC development leads to a loss of gut CD103+CD11b+ cDC2s, which was accompanied with impaired differentiation of both Rorγt+ Th17 cells and type 3 Rorγt+ Treg cells.

  • <em>Cx3cr1-</em>deficient microglia exhibit a premature aging transcriptome
    Open Access
    Cx3cr1-deficient microglia exhibit a premature aging transcriptome

    Stefka Gyoneva, Raghavendra Hosur, David Gosselin, Baohong Zhang, Zhengyu Ouyang, Anne C Cotleur, Michael Peterson, Norm Allaire, Ravi Challa, Patrick Cullen, Chris Roberts, Kelly Miao, Taylor L Reynolds, Christopher K Glass, Linda Burkly, Richard M Ransohoff

    Stefka Gyoneva ... Richard M Ransohoff

    Published 2 December 2019

    Gyoneva et al use RNA-seq to show that Cx3cr1-deficient microglia in young mice display a gene expression profile similar to microglia in aged mice, suggesting premature microglial aging.

  • The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response
    Open Access
    The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response

    Zilu Zhu, Ashima Shukla, Parham Ramezani-Rad, John R Apgar, Robert C Rickert

    Zilu Zhu ... Robert C Rickert

    Published 25 November 2019

    B cell–intrinsic AKT1/2 are essential for germinal center formation, antibody production and affinity maturation, and plasma cell differentiation.

  • The role of MHC class I recycling and Arf6 in cross-presentation by murine dendritic cells
    Open Access
    The role of MHC class I recycling and Arf6 in cross-presentation by murine dendritic cells

    Sebastian Montealegre, Anastasia Abramova, Valerie Manceau, Anne-Floor de Kanter, Peter van Endert

    Sebastian Montealegre ... Peter van Endert

    Published 18 November 2019

    MHC-I internalization and recycling in DCs neither requires Arf6 nor provides MHC-I to the Rab11+ endocytic recycling compartment; however, cross-presentation of immune complexes depends on Arf6.

  • MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy
    Open Access
    MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

    Mark Owyong, Jonathan Chou, Renske JE van den Bijgaart, Niwen Kong, Gizem Efe, Carrie Maynard, Dalit Talmi-Frank, Inna Solomonov, Charlotte Koopman, Elin Hadler-Olsen, Mark Headley, Charlene Lin, Chih-Yang Wang, Irit Sagi, Zena Werb, Vicki Plaks

    Mark Owyong ... Vicki Plaks

    Published 14 November 2019

    Inhibition of active MMP9 early during tumorigenesis suppresses tumor cell migration, invasion, and colony formation and tilts the balance towards anti-tumor immunity by activating CD8+ T cells.

  • Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease
    Open Access
    Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease

    Giorgia Renga, Vasilis Oikonomou, Silvia Moretti, Claudia Stincardini, Marina M Bellet, Marilena Pariano, Andrea Bartoli, Stefano Brancorsini, Paolo Mosci, Andrea Finocchi, Paolo Rossi, Claudio Costantini, Enrico Garaci, Allan L Goldstein, Luigina Romani

    Giorgia Renga ... Luigina Romani

    Published 12 November 2019

    This study demonstrates that thymosin β4 stabilizes HIF-1a to promote autophagy and up-regulate genes involved in tissue and mucosal barrier protection in chronic granulomatous disease.

  • Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice
    Open Access
    Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice

    Sambit Kumar Nanda, Tsvetana Petrova, Francesco Marchesi, Marek Gierlinski, Momchil Razsolkov, Katherine L Lee, Stephen W Wright, Vikram R Rao, Philip Cohen, J Simon C Arthur

    Sambit Kumar Nanda ... J Simon C Arthur

    Published 6 November 2019

    This article shows that liver and kidney damage in a lupus-prone mouse line occurs by different mechanisms and that only drugs targeting core components of signaling pathway, such as IRAK4, are able to suppress all facets of the disease.

  • Conservation of cell-intrinsic immune responses in diverse nonhuman primate species
    Open Access
    Conservation of cell-intrinsic immune responses in diverse nonhuman primate species

    Jenna M Gaska, Lance Parsons, Metodi Balev, Ann Cirincione, Wei Wang, Robert E Schwartz, Alexander Ploss

    Jenna M Gaska ... Alexander Ploss

    Published 24 October 2019

    The transcriptomic response of diverse nonhuman primate (NHP) species to poly(I:C) is highly conserved, and this novel RNA sequencing dataset will help improve NHP genome annotations.

  • Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsiveness
    Open Access
    Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsiveness

    William J Crisler, Emily M Eshleman, Laurel L Lenz

    William J Crisler ... Laurel L Lenz

    Published 4 October 2019

    IFNγ is shown to silence Ifngr1 transcription by altering enhancer occupancy, reducing myeloid cell IFNGR1 as a feedback mechanism to attenuate macrophage responses associated with inflammation.

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